Alabama Sen. Richard Shelby, seen here speaking to reporters in the Senate subway in October 2020, will not seek a seventh term in office in 2022.

WASHINGTON, DC – OCTOBER 21: Sen. Richard Shelby (R-AL) speaks to reporters in the Senate subway at the U.S. Capitol on October 21, 2020 in Washington, DC. The White House is hoping to reach a deal on a COVID-19 stimulus package in the next two days, after Senate Democrats blocked a $500 billion bill Wednesday afternoon. (Photo by Stefani Reynolds/Getty Images)