This cartoon, published around 1855, reflects the pervasive anti-Catholic sentiment of the era — perhaps best epitomized by the rise of the Know-Nothings, a nativist political party. Here, Catholics, led by the pope, are depicted as an invading force of foreigners, rebuffed by an Uncle Sam who likens them to the anti-Christ.

This cartoon, published around 1855, reflects the pervasive anti-Catholic sentiment of the era — perhaps best epitomized by the rise of the Know-Nothings, a nativist political party. Here, Catholics, led by the pope, are depicted as an invading force of foreigners, rebuffed by an Uncle Sam who likens them to the anti-Christ